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Locally administered nerve growth factor suppresses ginsenoside Rb1-enhanced peripheral nerve regeneration.
发布者：gaoyNRR 发布时间：2012年2月22日 来源：PubMed 神经生长因子联合人參皂苷Rb1 局部给药增强周围神经再生
来源：PubMed
来源杂志及出版时间：Am J Chin Med. 2003;31(5):665-73《美国中医杂志》
Key words: nerve growth factor; nerve regeneration
Abstract
A high-dose of nerve growth factor (NGF) mixed with ginsenoside Rb1 (GRb1) was encapsulated by collagen and placed in silicone rubber chambers, which were used to repair dissected Sprague-Dawley rat sciatic nerves with 15 mm gaps. Six weeks after surgery, no axons or Schwann cells were seen in these chambers. By comparison, nerves treated with collagen-GRb1 alone had regenerated axons and Schwann cells in their endoneurial areas. We suggest that excessive NGF may not promote but, rather, suppress developing nerves.
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